--- a/gfx/layers/Layers.h
+++ b/gfx/layers/Layers.h
@@ -862,17 +862,19 @@ public:
    * (This can be an overapproximation to the "true" visible region.)
    *
    * There is no general guarantee that drawing outside the bounds of the
    * visible region will be ignored. So if a layer draws outside the bounds
    * of its visible region, it needs to ensure that what it draws is valid.
    */
   virtual void SetVisibleRegion(const LayerIntRegion& aRegion)
   {
-    if (!mVisibleRegion.IsEqual(aRegion)) {
+    // IsEmpty is required otherwise we get invalidation glitches.
+    // See bug 1288464 for investigating why.
+    if (!mVisibleRegion.IsEqual(aRegion) || aRegion.IsEmpty()) {
       MOZ_LAYERS_LOG_IF_SHADOWABLE(this, ("Layer::Mutated(%p) VisibleRegion was %s is %s", this,
         mVisibleRegion.ToString().get(), aRegion.ToString().get()));
       mVisibleRegion = aRegion;
       Mutated();
     }
   }
 
   /**