--- a/devtools/server/actors/script.js
+++ b/devtools/server/actors/script.js
@@ -2,17 +2,17 @@
 /* vim: set ft=javascript ts=2 et sw=2 tw=80: */
 /* This Source Code Form is subject to the terms of the Mozilla Public
  * License, v. 2.0. If a copy of the MPL was not distributed with this
  * file, You can obtain one at http://mozilla.org/MPL/2.0/. */
 
 "use strict";
 
 const Services = require("Services");
-const { Cc, Ci, Cu, components, ChromeWorker } = require("chrome");
+const { Cc, Ci, Cu, Cr, components, ChromeWorker } = require("chrome");
 const { ActorPool, OriginalLocation, GeneratedLocation } = require("devtools/server/actors/common");
 const { BreakpointActor } = require("devtools/server/actors/breakpoint");
 const { FrameActor } = require("devtools/server/actors/frame");
 const { ObjectActor, createValueGrip, longStringGrip } = require("devtools/server/actors/object");
 const { DebuggerServer } = require("devtools/server/main");
 const DevToolsUtils = require("devtools/shared/DevToolsUtils");
 const { assert, dumpn, update, fetch } = DevToolsUtils;
 const { dirname, joinURI } = require("devtools/shared/path");
@@ -1841,16 +1841,23 @@ ThreadActor.prototype = {
         break;
       }
     }
 
     if (willBeCaught && this._options.ignoreCaughtExceptions) {
       return undefined;
     }
 
+    // NS_ERROR_NO_INTERFACE exceptions are a special case in browser code,
+    // since they're almost always thrown by QueryInterface functions, and
+    // handled cleanly by native code.
+    if (aValue == Cr.NS_ERROR_NO_INTERFACE) {
+      return undefined;
+    }
+
     const generatedLocation = this.sources.getFrameLocation(aFrame);
     const { originalSourceActor } = this.unsafeSynchronize(this.sources.getOriginalLocation(
       generatedLocation));
     const url = originalSourceActor ? originalSourceActor.url : null;
 
     if (this.sources.isBlackBoxed(url)) {
       return undefined;
     }

copy from devtools/server/tests/unit/test_pause_exceptions-02.js
copy to devtools/server/tests/unit/test_ignore_no_interface_exceptions.js
--- a/devtools/server/tests/unit/test_pause_exceptions-02.js
+++ b/devtools/server/tests/unit/test_ignore_no_interface_exceptions.js
@@ -1,27 +1,28 @@
 /* Any copyright is dedicated to the Public Domain.
    http://creativecommons.org/publicdomain/zero/1.0/ */
 
 /**
- * Test that setting pauseOnExceptions to true when the debugger isn't in a
- * paused state will cause the debuggee to pause when an exceptions is thrown.
+ * Test that the debugger automatically ignores NS_ERROR_NO_INTERFACE
+ * exceptions, but not normal ones.
  */
 
+
 var gDebuggee;
 var gClient;
 var gThreadClient;
 
 function run_test()
 {
   initTestDebuggerServer();
-  gDebuggee = addTestGlobal("test-stack");
+  gDebuggee = addTestGlobal("test-no-interface");
   gClient = new DebuggerClient(DebuggerServer.connectPipe());
   gClient.connect().then(function() {
-    attachTestTabAndResume(gClient, "test-stack", function(aResponse, aTabClient, aThreadClient) {
+    attachTestTabAndResume(gClient, "test-no-interface", function(aResponse, aTabClient, aThreadClient) {
       gThreadClient = aThreadClient;
       test_pause_frame();
     });
   });
   do_test_pending();
 }
 
 function test_pause_frame()
@@ -31,17 +32,23 @@ function test_pause_frame()
       do_check_eq(aPacket.why.type, "exception");
       do_check_eq(aPacket.why.exception, 42);
       gThreadClient.resume(function () {
         finishClient(gClient);
       });
     });
 
     gDebuggee.eval("(" + function() {
+      function QueryInterface() {
+        throw Components.results.NS_ERROR_NO_INTERFACE;
+      }
       function stopMe() {
         throw 42;
       };
       try {
+        QueryInterface();
+      } catch (e) {}
+      try {
         stopMe();
       } catch (e) {}
     } + ")()");
   });
 }

--- a/devtools/server/tests/unit/xpcshell.ini
+++ b/devtools/server/tests/unit/xpcshell.ini
@@ -234,16 +234,17 @@ reason = bug 820380
 [test_profiler_events-01.js]
 [test_profiler_events-02.js]
 [test_profiler_getbufferinfo.js]
 [test_profiler_getfeatures.js]
 [test_profiler_getsharedlibraryinformation.js]
 [test_unsafeDereference.js]
 [test_add_actors.js]
 [test_ignore_caught_exceptions.js]
+[test_ignore_no_interface_exceptions.js]
 [test_requestTypes.js]
 reason = bug 937197
 [test_layout-reflows-observer.js]
 [test_protocolSpec.js]
 [test_registerClient.js]
 [test_client_request.js]
 [test_monitor_actor.js]
 [test_symbols-01.js]