--- a/dom/payments/test/browser.ini
+++ b/dom/payments/test/browser.ini
@@ -1,8 +1,8 @@
 [DEFAULT]
 # skip-if !e10s will be removed once non-e10s is supported
-skip-if = !e10s
+skip-if = !e10s || !nightly_build
 support-files =
   head.js
   simple_payment_request.html
 
 [browser_payment_in_different_tabs.js]

--- a/dom/payments/test/mochitest.ini
+++ b/dom/payments/test/mochitest.ini
@@ -1,11 +1,11 @@
 [DEFAULT]
 # skip-if !e10s will be removed once non-e10s is supported
-skip-if = !e10s
+skip-if = !e10s || !nightly_build
 scheme = https
 support-files =
   simple_payment_request.html
   echo_payment_request.html
   BasiccardChromeScript.js
   ConstructorChromeScript.js
   CurrencyAmountValidationChromeScript.js
   DefaultData.js