--- a/testing/marionette/harness/marionette_harness/tests/unit/unit-tests.ini
+++ b/testing/marionette/harness/marionette_harness/tests/unit/unit-tests.ini
@@ -69,16 +69,17 @@ skip-if = appname == 'fennec'
 [test_window_maximize.py]
 skip-if = appname == 'fennec'
 [test_window_minimize.py]
 skip-if = appname == 'fennec' || headless
 [test_window_status_content.py]
 [test_window_status_chrome.py]
 
 [test_screenshot.py]
+skip-if = appname == 'fennec' && debug # Bug 1454680
 [test_cookies.py]
 [test_title.py]
 [test_title_chrome.py]
 skip-if = appname == 'fennec'
 [test_window_type_chrome.py]
 skip-if = appname == 'fennec'
 [test_implicit_waits.py]
 [test_wait.py]