--- a/moz.configure
+++ b/moz.configure
@@ -431,16 +431,22 @@ def tup_is_ldpreload(tup):
                               'of tup compiled with the ldpreload dependency '
                               'checker. Either compile tup locally with '
                               'CONFIG_TUP_SERVER=ldpreload in your tup.config '
                               'file, or use the version from the toolchain '
                               'task via |./mach artifact toolchain '
                               '--from-build linux64-tup|')
     return True
 
+@depends_if(tup, using_sccache)
+def tup_and_sccache(tup, using_sccache):
+    if tup and using_sccache:
+        die('Cannot use sccache with tup yet. Please disable sccache or use '
+            'the make backend until it is supported.')
+
 # watchman detection
 # ==============================================================
 
 option(env='WATCHMAN', nargs=1, help='Path to the watchman program')
 
 @depends('WATCHMAN')
 @checking('for watchman', callback=lambda w: w.path if w else 'not found')
 def watchman(prog):