--- a/browser/components/preferences/siteDataSettings.js
+++ b/browser/components/preferences/siteDataSettings.js
@@ -258,16 +258,17 @@ let gSiteDataSettings = {
 
   close() {
     window.close();
   },
 
   onClickTreeCol(e) {
     this._sortSites(this._sites, e.target);
     this._buildSitesList(this._sites);
+    this._list.clearSelection();
   },
 
   onCommandSearch() {
     this._buildSitesList(this._sites);
     this._list.clearSelection();
   },
 
   onClickRemoveSelected() {