--- a/testing/marionette/harness/marionette_harness/tests/unit/test_navigation.py
+++ b/testing/marionette/harness/marionette_harness/tests/unit/test_navigation.py
@@ -750,16 +750,17 @@ class TestPageLoadStrategy(BaseNavigatio
         self.marionette.delete_session()
         self.marionette.start_session({"pageLoadStrategy": "normal"})
 
         self.marionette.navigate(self.test_page_slow_resource)
         self.assertEqual(self.test_page_slow_resource, self.marionette.get_url())
         self.assertEqual("complete", self.ready_state)
         self.marionette.find_element(By.ID, "slow")
 
+    @skip("Bug 1422741 - Causes following tests to fail in loading remote browser")
     @run_if_e10s("Requires e10s mode enabled")
     def test_strategy_after_remoteness_change(self):
         """Bug 1378191 - Reset of capabilities after listener reload"""
         self.marionette.delete_session()
         self.marionette.start_session({"pageLoadStrategy": "eager"})
 
         # Trigger a remoteness change which will reload the listener script
         self.assertTrue(self.is_remote_tab, "Initial tab doesn't have remoteness flag set")