--- a/taskcluster/ci/test/mochitest.yml
+++ b/taskcluster/ci/test/mochitest.yml
@@ -121,16 +121,20 @@ mochitest-browser-chrome:
             default: default
 
 browser-instrumentation:
     description: "Extra instrumentation for a browser-chrome run (XUL, XBL, etc)"
     suite: mochitest/browser-chrome-instrumentation
     treeherder-symbol: tc-M(inst)
     loopback-video: true
     tier: 3
+    run-on-projects:
+        by-test-platform:
+            windows.*-nightly/.*: ["mozilla-central"]
+            default: []
     max-run-time: 14400
     mozharness:
         mochitest-flavor: browser
     allow-software-gl-layers: false
 
 browser-screenshots:
     description: "Browser Screenshots"
     suite: mochitest/browser-chrome-screenshots

--- a/taskcluster/ci/test/test-platforms.yml
+++ b/taskcluster/ci/test/test-platforms.yml
@@ -216,17 +216,16 @@ windows10-64/debug:
         - windows-tests
         - mochitest-headless
 
 windows10-64/opt:
     build-platform: win64/opt
     test-sets:
         - awsy
         - desktop-screenshot-capture
-        - desktop-instrumentation
         - windows-talos
         - windows-talos-stylo-disabled
         - windows-tests
         - mochitest-headless
 
 windows10-64-pgo/opt:
     build-platform: win64-pgo/opt
     test-sets:
@@ -236,16 +235,17 @@ windows10-64-pgo/opt:
         - windows-talos-stylo-disabled
         - windows-tests
 
 windows10-64-nightly/opt:
     build-platform: win64-nightly/opt
     test-sets:
         - awsy
         - desktop-screenshot-capture
+        - desktop-instrumentation
         - windows-tests
 
 windows10-64-devedition/opt:
     build-platform: win64-devedition-nightly/opt
     test-sets:
         - desktop-screenshot-capture
         - windows-tests