--- a/browser/components/translation/BingTranslator.jsm
+++ b/browser/components/translation/BingTranslator.jsm
@@ -7,16 +7,18 @@
 this.EXPORTED_SYMBOLS = [ "BingTranslator" ];
 
 ChromeUtils.import("resource://gre/modules/Services.jsm");
 ChromeUtils.import("resource://gre/modules/Log.jsm");
 ChromeUtils.import("resource://gre/modules/PromiseUtils.jsm");
 ChromeUtils.import("resource://services-common/utils.js");
 ChromeUtils.import("resource://gre/modules/Http.jsm");
 
+Cu.importGlobalProperties(["XMLHttpRequest"]);
+
 // The maximum amount of net data allowed per request on Bing's API.
 const MAX_REQUEST_DATA = 5000; // Documentation says 10000 but anywhere
                                // close to that is refused by the service.
 
 // The maximum number of chunks allowed to be translated in a single
 // request.
 const MAX_REQUEST_CHUNKS = 1000; // Documentation says 2000.
 
@@ -124,17 +126,17 @@ this.BingTranslator.prototype = {
    * service is unavailable (zero balance on the key or request credentials are
    * not in an active state) and calling the function to resolve the promise
    * returned by the public `translate()` method when there's no pending.
    * request left.
    *
    * @param   aError   [optional] The XHR object of the request that failed.
    */
   _chunkFailed(aError) {
-    if (aError instanceof Ci.nsIXMLHttpRequest &&
+    if (aError instanceof XMLHttpRequest &&
         [400, 401].includes(aError.status)) {
       let body = aError.responseText;
       if (body && body.includes("TranslateApiException") &&
           (body.includes("balance") || body.includes("active state")))
         this._serviceUnavailable = true;
     }
 
     this._checkIfFinished();

--- a/browser/components/translation/YandexTranslator.jsm
+++ b/browser/components/translation/YandexTranslator.jsm
@@ -7,16 +7,18 @@
 this.EXPORTED_SYMBOLS = [ "YandexTranslator" ];
 
 ChromeUtils.import("resource://gre/modules/Services.jsm");
 ChromeUtils.import("resource://gre/modules/Log.jsm");
 ChromeUtils.import("resource://gre/modules/PromiseUtils.jsm");
 ChromeUtils.import("resource://services-common/utils.js");
 ChromeUtils.import("resource://gre/modules/Http.jsm");
 
+Cu.importGlobalProperties(["XMLHttpRequest"]);
+
 // The maximum amount of net data allowed per request on Bing's API.
 const MAX_REQUEST_DATA = 5000; // Documentation says 10000 but anywhere
                                // close to that is refused by the service.
 
 // The maximum number of chunks allowed to be translated in a single
 // request.
 const MAX_REQUEST_CHUNKS = 1000; // Documentation says 2000.
 
@@ -133,17 +135,17 @@ this.YandexTranslator.prototype = {
    * service is unavailable (zero balance on the key or request credentials are
    * not in an active state) and calling the function to resolve the promise
    * returned by the public `translate()` method when there are no pending
    * requests left.
    *
    * @param   aError   [optional] The XHR object of the request that failed.
    */
   _chunkFailed(aError) {
-    if (aError instanceof Ci.nsIXMLHttpRequest) {
+    if (aError instanceof XMLHttpRequest) {
       let body = aError.responseText;
       let json = { code: 0 };
       try {
         json = JSON.parse(body);
       } catch (e) {}
 
       if (json.code && YANDEX_PERMANENT_ERRORS.includes(json.code))
         this._serviceUnavailable = true;

--- a/browser/experiments/Experiments.jsm
+++ b/browser/experiments/Experiments.jsm
@@ -9,16 +9,18 @@ this.EXPORTED_SYMBOLS = [
 ];
 
 ChromeUtils.import("resource://gre/modules/XPCOMUtils.jsm");
 ChromeUtils.import("resource://gre/modules/Services.jsm");
 ChromeUtils.import("resource://gre/modules/osfile.jsm");
 ChromeUtils.import("resource://gre/modules/Log.jsm");
 ChromeUtils.import("resource://gre/modules/AsyncShutdown.jsm");
 
+Cu.importGlobalProperties(["XMLHttpRequest"]);
+
 ChromeUtils.defineModuleGetter(this, "UpdateUtils",
                                "resource://gre/modules/UpdateUtils.jsm");
 ChromeUtils.defineModuleGetter(this, "AddonManager",
                                "resource://gre/modules/AddonManager.jsm");
 ChromeUtils.defineModuleGetter(this, "AddonManagerPrivate",
                                "resource://gre/modules/AddonManager.jsm");
 ChromeUtils.defineModuleGetter(this, "TelemetryEnvironment",
                                "resource://gre/modules/TelemetryEnvironment.jsm");
@@ -932,17 +934,17 @@ Experiments.Experiments.prototype = {
   },
 
   /*
    * Helper function to make HTTP GET requests. Returns a promise that is resolved with
    * the responseText when the request is complete.
    */
   _httpGetRequest(url) {
     this._log.trace("httpGetRequest(" + url + ")");
-    let xhr = Cc["@mozilla.org/xmlextras/xmlhttprequest;1"].createInstance(Ci.nsIXMLHttpRequest);
+    let xhr = new XMLHttpRequest();
 
     this._networkRequest = xhr;
     return new Promise((resolve, reject) => {
 
       let log = this._log;
       let errorhandler = (evt) => {
         log.error("httpGetRequest::onError() - Error making request to " + url + ": " + evt.type);
         reject(new Error("Experiments - XHR error for " + url + " - " + evt.type));

--- a/browser/modules/ContentSearch.jsm
+++ b/browser/modules/ContentSearch.jsm
@@ -5,16 +5,18 @@
 
 this.EXPORTED_SYMBOLS = [
   "ContentSearch",
 ];
 
 ChromeUtils.import("resource://gre/modules/Services.jsm");
 ChromeUtils.import("resource://gre/modules/XPCOMUtils.jsm");
 
+Cu.importGlobalProperties(["XMLHttpRequest"]);
+
 ChromeUtils.defineModuleGetter(this, "FormHistory",
   "resource://gre/modules/FormHistory.jsm");
 ChromeUtils.defineModuleGetter(this, "PrivateBrowsingUtils",
   "resource://gre/modules/PrivateBrowsingUtils.jsm");
 ChromeUtils.defineModuleGetter(this, "SearchSuggestionController",
   "resource://gre/modules/SearchSuggestionController.jsm");
 
 const INBOUND_MESSAGE = "ContentSearch";
@@ -512,18 +514,17 @@ this.ContentSearch = {
     return obj;
   },
 
   _arrayBufferFromDataURI(uri) {
     if (!uri) {
       return Promise.resolve(null);
     }
     return new Promise(resolve => {
-      let xhr = Cc["@mozilla.org/xmlextras/xmlhttprequest;1"].
-                createInstance(Ci.nsIXMLHttpRequest);
+      let xhr = new XMLHttpRequest();
       xhr.open("GET", uri, true);
       xhr.responseType = "arraybuffer";
       xhr.onload = () => {
         resolve(xhr.response);
       };
       xhr.onerror = xhr.onabort = xhr.ontimeout = () => {
         resolve(null);
       };

--- a/browser/modules/test/browser/browser_ContentSearch.js
+++ b/browser/modules/test/browser/browser_ContentSearch.js
@@ -1,16 +1,19 @@
 /* This Source Code Form is subject to the terms of the Mozilla Public
  * License, v. 2.0. If a copy of the MPL was not distributed with this
  * file, You can obtain one at http://mozilla.org/MPL/2.0/. */
 
 const TEST_MSG = "ContentSearchTest";
 const CONTENT_SEARCH_MSG = "ContentSearch";
 const TEST_CONTENT_SCRIPT_BASENAME = "contentSearch.js";
 
+const { utils: Cu } = Components;
+Cu.importGlobalProperties(["XMLHttpRequest"]);
+
 var gMsgMan;
 /* import-globals-from ../../../components/search/test/head.js */
 Services.scriptloader.loadSubScript(
   "chrome://mochitests/content/browser/browser/components/search/test/head.js",
   this);
 
 let originalEngine = Services.search.currentEngine;
 
@@ -388,18 +391,17 @@ var currentEngineObj = async function() 
   };
 };
 
 function arrayBufferFromDataURI(uri) {
   if (!uri) {
     return Promise.resolve(null);
   }
   return new Promise(resolve => {
-    let xhr = Cc["@mozilla.org/xmlextras/xmlhttprequest;1"].
-              createInstance(Ci.nsIXMLHttpRequest);
+    let xhr = new XMLHttpRequest();
     xhr.open("GET", uri, true);
     xhr.responseType = "arraybuffer";
     xhr.onerror = () => {
       resolve(null);
     };
     xhr.onload = () => {
       resolve(xhr.response);
     };