--- a/devtools/shared/discovery/tests/unit/xpcshell.ini
+++ b/devtools/shared/discovery/tests/unit/xpcshell.ini
@@ -1,6 +1,7 @@
 [DEFAULT]
 tags = devtools
 head = ../../../tests/shared-xpcshell-head.js
 firefox-appdir = browser
+skip-if = toolkit == 'android' # Bug 1380687 - xpcshell-tests can not run for system addons on android
 
 [test_discovery.js]

--- a/devtools/shared/platform/content/test/xpcshell.ini
+++ b/devtools/shared/platform/content/test/xpcshell.ini
@@ -1,6 +1,7 @@
 [DEFAULT]
 tags = devtools
 head = ../../../tests/shared-xpcshell-head.js
 firefox-appdir = browser
+skip-if = toolkit == 'android' # Bug 1380687 - xpcshell-tests can not run for system addons on android
 
 [test_stack.js]

--- a/devtools/shared/qrcode/tests/unit/xpcshell.ini
+++ b/devtools/shared/qrcode/tests/unit/xpcshell.ini
@@ -1,6 +1,7 @@
 [DEFAULT]
 tags = devtools
 head = ../../../tests/shared-xpcshell-head.js
 firefox-appdir = browser
+skip-if = toolkit == 'android' # Bug 1380687 - xpcshell-tests can not run for system addons on android
 
 [test_encode.js]

--- a/devtools/shared/security/tests/unit/xpcshell.ini
+++ b/devtools/shared/security/tests/unit/xpcshell.ini
@@ -1,11 +1,12 @@
 [DEFAULT]
 tags = devtools
 head = ../../../tests/shared-xpcshell-head.js  head_dbg.js
 firefox-appdir = browser
+skip-if = toolkit == 'android' # Bug 1380687 - xpcshell-tests can not run for system addons on android
 
 support-files=
   testactors.js
 
 [test_encryption.js]
 [test_oob_cert_auth.js]
 skip-if = (toolkit == 'android' && !debug) # Bug 1141544: Re-enable when buildbot tests are gone